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Concurrent administration of oral hypoglycemic agent (Tolbutamide); should be cautiously administered to patients with diabetes because ursodeoxycholic acid may increase the effects of oral hypoglycemic agents.
The following may reduce the absorption of this drug: Cholestyramine, cholestipol, charcoal, aluminum hydroxide and magnesium-based antacids; cholesterol-reducing drugs in bile (e.g. Oral contraceptives containing estrogens) or cholesterol-reducing drugs in serum (e.g. clofibrate); drugs which induce liver injury.
